With the win, the Cyclones will play the Tar Heels in the championship, while the Green and White will take on Oregon in the third-place game on Sunday at 1 p.m.
Senior forward Malik Hall out for next three weeks due to foot injury.
Not only is MSU tasked with facing two top-18 teams, the Spartans will also be without sophomore forward Matilda Ekh.
Michigan State will face Alabama in the first round of the Phil Knight Invitational at the Moda Center.
The last time the event was awarded to Detroit was in 2009 when Michigan State overcame the University of Connecticut in the semifinals, 82-73.
Michigan State makes its first appearance in the AP Poll at No. 12.
Senior Guard Tyson Walker aids in Michigan State's victory over Villanova Friday night.
Michigan State hits the road for the first time Saturday to take on Central Michigan.
Michigan State led by 16 points with eight minutes to play, but Villanova clawed back all the way to to the final buzzer.
Michigan State rolled to another victory, defeating Florida A&M 109-44.
MSU will host the Villanova Wildcats Friday at 8 p.m. at the Breslin Center.
Michigan State can secure a 5-0 start to the season with a win over Florida A&M on Thursday night.
Junior center Mady Sissoko is showing immense growth three games into MSU's 2022-23 season.
After a slow start, MSU pulled away by limiting Oakland to just nine combined points in the second and third quarters.
MSU upset the Kentucky Wildcats on Tuesday night at Gainbridge Fieldhouse.
Michigan State hosts Oakland at 7 p.m. at the Breslin Center.
MSU heads to Indianapolis to face No. 4 Kentucky with Oscar Tshiebwe's status up in the air.
A third generation Spartan, Lieutenant Commander Sean Newman didn't hesitate when given the opportunity to watch MSU aboard the USS Abraham Lincoln.
Five Spartans had at least 11 points as MSU moved to 3-0 to start the season.
The last time the Broncos came away with a win against MSU was 40 years ago in 1982 in Grand Rapids. MSU is 7-3 all-time at home against Western.