The No. 24 MSU wrestling team fell to No. 5 Missouri, 29-3, on Saturday.
The matchup was the opening round of the NWCA Cliff Keen National Duals, a double-elimination event featuring the top 16 teams in the nation.
Redshirt freshman Andy Simmons, 141 pounds, captured the only win for MSU with a 7-5 defeat of J.P. Reese.
In the consolation match, the Spartans again fell, 20-15, to Central Michigan.
MSU hosts Minnesota at 7 p.m. Friday and Illinois at 1 p.m. Sunday at Jenison Field House.