The Spartans matched their competition for much of the first two periods but could never tie or take a lead, leaving the door open for the Wolverines to pull away in the third.
The Spartans have adopted a "business as usual" approach in one of their most anticipated series of the year.
Michigan State faced its first Big Ten opponent of the season of the 2021-22 season last weekend, heading to Columbus to face off against Ohio State.
The series begins Friday night, where the puck is set to drop at 6 p.m. in Columbus. The game will be streamed via BTN+.