Four MSU players put up double-digit points, allowing the Spartans to maintain their momentum throughout the game and knock off a top-ranked opponent for the first time this season.
With the win, MSU hands Indiana its first loss of the season, advancing to 9-5 overall and 1-2 Big Ten play.
The Spartans return to Big Ten play Thursday with tipoff set for 3 p.m. at the Breslin Center.
The Spartans will look to carry the momentum from back-to-back non-conference wins as they return to Big Ten play next week.
The Spartans snapped their five-game losing streak with a dominant victory over Detroit Mercy.
The Spartans are looking to snap a five-game losing streak without junior guard Gabby Elliott, who suffered a season-ending ACL injury against Ohio State.
Michigan State had multiple opportunities to tie or take the lead late versus No. 3 Ohio State, but the Spartans couldn't score more than two points in the last 1:44 of Sunday's game.
Michigan State cleaned up turnover issues in the second half, but couldn't sneak past No. 3 Ohio State.
An upset over No. 3 Ohio State would also end a four-game losing skid.
Michigan State stormed in the fourth quarter to force overtime, but ultimately came up short in the end.
Michigan State opens Big Ten play with a home battle versus Purdue.
Kamaria McDaniel has 54 combined points in the last two games, but both efforts have led to a loss.
Kamaria McDaniel scored 26 points, but MSU came up just short at home versus Georgia Tech.
Michigan State welcomes Georgia Tech to the Breslin Center Thursday night.
Kamaria McDaniel's 28 points weren't enough as MSU dropped its second game of the Phil Knight Invitational.
Michigan State will conclude the Phil Knight Invitational Sunday afternoon.
With the win, the Cyclones will play the Tar Heels in the championship, while the Green and White will take on Oregon in the third-place game on Sunday at 1 p.m.
Not only is MSU tasked with facing two top-18 teams, the Spartans will also be without sophomore forward Matilda Ekh.
Michigan State hits the road for the first time Saturday to take on Central Michigan.
Michigan State rolled to another victory, defeating Florida A&M 109-44.